Abstract
The visible-light-mediated three-component dicarbofunctionalization of styrenes using simple benzylic radicals is described. Notably, this work describes a rare example of undirected dicarbofunctionalization using unsubstituted benzyl radicals. Key to the success of this strategy was the rational design and use of benzylic pyridinium salts as radical precursors. Using this approach, abundant styrenes, electron-rich heterocycles, and benzylic amines were combined to rapidly afford a number of densely functionalized 1,1-diarylalkanes. A dipeptide-derived pyridinium salt was applied in this transformation, which resembles a visible-light-mediated deaminative generation of radicals from peptides.
Original language | English |
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Pages (from-to) | 236-241 |
Number of pages | 6 |
Journal | ACS Catalysis |
Volume | 9 |
Issue number | 1 |
Early online date | 26 Nov 2018 |
DOIs | |
Publication status | Published - 4 Jan 2019 |
Bibliographical note
© 2018 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.Keywords
- deamination
- dicarbofunctionalization
- photoredox catalysis
- redox-active
- visible-light
Profiles
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Michael John James
- Chemistry - Leverhulme Early Career Research Fellow, Former employee
Person: Research