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Abstract
The synthesis of 2-azetidinones (β-lactams) from simple acrylamide starting materials by visible-light mediated energy transfer catalysis is reported. The reaction features a C(sp3 )-H functionalization via a variation of the Norrish-Yang photocyclization involving a carbon-to-carbon 1,5-hydrogen atom transfer (supported by deuterium labelling and DFT calculations) and can be used for the construction of a diverse range of β-lactam products.
Original language | English |
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Article number | e202213086 |
Journal | Angewandte Chemie International Edition |
Volume | 61 |
Issue number | 48 |
Early online date | 26 Oct 2022 |
DOIs | |
Publication status | Published - 18 Nov 2022 |
Bibliographical note
© 2022 Wiley-VCH GmbH.Projects
- 1 Finished
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Rings around the globe: ‘growing’ macrocyclic drugs from York to Cape Town
1/02/20 → 1/03/23
Project: Research project (funded) › Research