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Visible-light-induced CO release from a therapeutically viable tryptophan-derived manganese(I) carbonyl (TryptoCORM) exhibiting potent inhibition against E. coli

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JournalChemistry - A European Journal
DateE-pub ahead of print - 3 Oct 2014
DatePublished (current) - 10 Nov 2014
Issue number46
Volume20
Number of pages8
Pages (from-to)15061-15068
Early online date3/10/14
Original languageEnglish

Abstract

The first visible-light-activated carbon-monoxidereleasing molecule (CO-RM) to exhibit a potent effect against Escherichia coli is described. The easily prepared tryptophanderived manganese-containing complex (TryptoCORM) released 1.4 moles of CO at 465 nm, and 2 moles at 400 nm. A comprehensive synthetic, mechanistic and microbiological study into the behaviour of TryptoCORM is reported. The complex is thermally stable (i.e., does not release CO in solution in the absence of light), shows low toxicity against mammalian cells and releases tryptophan on photoinduced degradation, all of which point to TryptoCORM being therapeutically viable.

    Research areas

  • Carbon monoxide, Circular dichroism, Kinetics, Photochemistry

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