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Journal | ACS Catalysis |
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Date | Accepted/In press - 26 Nov 2018 |
Date | E-pub ahead of print - 26 Nov 2018 |
Date | Published (current) - 4 Jan 2019 |
Issue number | 1 |
Volume | 9 |
Number of pages | 6 |
Pages (from-to) | 236-241 |
Early online date | 26/11/18 |
Original language | English |
The visible-light-mediated three-component dicarbofunctionalization of styrenes using simple benzylic radicals is described. Notably, this work describes a rare example of undirected dicarbofunctionalization using unsubstituted benzyl radicals. Key to the success of this strategy was the rational design and use of benzylic pyridinium salts as radical precursors. Using this approach, abundant styrenes, electron-rich heterocycles, and benzylic amines were combined to rapidly afford a number of densely functionalized 1,1-diarylalkanes. A dipeptide-derived pyridinium salt was applied in this transformation, which resembles a visible-light-mediated deaminative generation of radicals from peptides.
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