Where asymmetry in gene expression originates

I  Barak; A J  Wilkinson

doi:10.1111/j.1365-2958.2005.04687.x

Where asymmetry in gene expression originates

I Barak, A J Wilkinson

Chemistry

Research output: Contribution to journal › Literature review › peer-review

Abstract

A general problem in developmental biology concerns the process by which cells of one type divide to give dissimilar daughter cells. Even though these daughter cells may be genetically identical, they can differ morphologically and physiologically and have different fates. As one of the simplest differentiation processes, Bacillus subtilis sporulation represents an excellent model system for studying cell differentiation. Several decades of study of this process have provided insight into cell cycle regulation and development. This review summarizes important advances in our understanding of asymmetric gene expression during spore formation with an emphasis on developmental stages that lead to asymmetric septum formation and especially to activation of the first compartment-specific sigma factor - sigma(F).

Original language	English
Pages (from-to)	611-620
Number of pages	10
Journal	Molecular Microbiology
Volume	57
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2958.2005.04687.x
Publication status	Published - Aug 2005

Keywords

CELL-SPECIFIC TRANSCRIPTION
ANTI-SIGMA FACTOR
DIFFERENTIATION PROTEIN SPOIIE
SPORULATING BACILLUS-SUBTILIS
ANTISIGMA FACTOR SPOIIAB
DNA TRANSLOCASE SPOIIIE
SPOROSARCINA-UREAE
CHROMOSOME SEGREGATION
BACTERIAL PROTEIN
CRYSTAL-STRUCTURE

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10.1111/j.1365-2958.2005.04687.x

Cite this

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title = "Where asymmetry in gene expression originates",

abstract = "A general problem in developmental biology concerns the process by which cells of one type divide to give dissimilar daughter cells. Even though these daughter cells may be genetically identical, they can differ morphologically and physiologically and have different fates. As one of the simplest differentiation processes, Bacillus subtilis sporulation represents an excellent model system for studying cell differentiation. Several decades of study of this process have provided insight into cell cycle regulation and development. This review summarizes important advances in our understanding of asymmetric gene expression during spore formation with an emphasis on developmental stages that lead to asymmetric septum formation and especially to activation of the first compartment-specific sigma factor - sigma(F).",

keywords = "CELL-SPECIFIC TRANSCRIPTION, ANTI-SIGMA FACTOR, DIFFERENTIATION PROTEIN SPOIIE, SPORULATING BACILLUS-SUBTILIS, ANTISIGMA FACTOR SPOIIAB, DNA TRANSLOCASE SPOIIIE, SPOROSARCINA-UREAE, CHROMOSOME SEGREGATION, BACTERIAL PROTEIN, CRYSTAL-STRUCTURE",

author = "I Barak and Wilkinson, {A J}",

year = "2005",

month = aug,

doi = "10.1111/j.1365-2958.2005.04687.x",

language = "English",

volume = "57",

pages = "611--620",

journal = "Molecular Microbiology",

issn = "0950-382X",

publisher = "Wiley-Blackwell",

number = "3",

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TY - JOUR

T1 - Where asymmetry in gene expression originates

AU - Barak, I

AU - Wilkinson, A J

PY - 2005/8

Y1 - 2005/8

N2 - A general problem in developmental biology concerns the process by which cells of one type divide to give dissimilar daughter cells. Even though these daughter cells may be genetically identical, they can differ morphologically and physiologically and have different fates. As one of the simplest differentiation processes, Bacillus subtilis sporulation represents an excellent model system for studying cell differentiation. Several decades of study of this process have provided insight into cell cycle regulation and development. This review summarizes important advances in our understanding of asymmetric gene expression during spore formation with an emphasis on developmental stages that lead to asymmetric septum formation and especially to activation of the first compartment-specific sigma factor - sigma(F).

AB - A general problem in developmental biology concerns the process by which cells of one type divide to give dissimilar daughter cells. Even though these daughter cells may be genetically identical, they can differ morphologically and physiologically and have different fates. As one of the simplest differentiation processes, Bacillus subtilis sporulation represents an excellent model system for studying cell differentiation. Several decades of study of this process have provided insight into cell cycle regulation and development. This review summarizes important advances in our understanding of asymmetric gene expression during spore formation with an emphasis on developmental stages that lead to asymmetric septum formation and especially to activation of the first compartment-specific sigma factor - sigma(F).

KW - CELL-SPECIFIC TRANSCRIPTION

KW - ANTI-SIGMA FACTOR

KW - DIFFERENTIATION PROTEIN SPOIIE

KW - SPORULATING BACILLUS-SUBTILIS

KW - ANTISIGMA FACTOR SPOIIAB

KW - DNA TRANSLOCASE SPOIIIE

KW - SPOROSARCINA-UREAE

KW - CHROMOSOME SEGREGATION

KW - BACTERIAL PROTEIN

KW - CRYSTAL-STRUCTURE

U2 - 10.1111/j.1365-2958.2005.04687.x

DO - 10.1111/j.1365-2958.2005.04687.x

M3 - Literature review

VL - 57

SP - 611

EP - 620

JO - Molecular Microbiology

JF - Molecular Microbiology

SN - 0950-382X

IS - 3

ER -