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Where asymmetry in gene expression originates

Research output: Contribution to journalLiterature review

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JournalMolecular Microbiology
DatePublished - Aug 2005
Issue number3
Volume57
Number of pages10
Pages (from-to)611-620
Original languageEnglish

Abstract

A general problem in developmental biology concerns the process by which cells of one type divide to give dissimilar daughter cells. Even though these daughter cells may be genetically identical, they can differ morphologically and physiologically and have different fates. As one of the simplest differentiation processes, Bacillus subtilis sporulation represents an excellent model system for studying cell differentiation. Several decades of study of this process have provided insight into cell cycle regulation and development. This review summarizes important advances in our understanding of asymmetric gene expression during spore formation with an emphasis on developmental stages that lead to asymmetric septum formation and especially to activation of the first compartment-specific sigma factor - sigma(F).

    Research areas

  • CELL-SPECIFIC TRANSCRIPTION, ANTI-SIGMA FACTOR, DIFFERENTIATION PROTEIN SPOIIE, SPORULATING BACILLUS-SUBTILIS, ANTISIGMA FACTOR SPOIIAB, DNA TRANSLOCASE SPOIIIE, SPOROSARCINA-UREAE, CHROMOSOME SEGREGATION, BACTERIAL PROTEIN, CRYSTAL-STRUCTURE

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