Why deciphering complexity in Pd-catalyzed cross-coupling reactions matters

Ian James Stewart Fairlamb; Mark Ford

doi:10.1016/j.checat.2024.101255

Why deciphering complexity in Pd-catalyzed cross-coupling reactions matters

Ian James Stewart Fairlamb^*, Mark Ford

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Pd-catalyzed cross-couplings have revolutionized chemical synthesis. Realizing a world that can make any organic molecular structure will undoubtedly require Pd-catalyzed cross-coupling as a tool to enable this high-brow vision. Here, Ian Fairlamb (professor at the University of York) and Mark Ford (Distinguished Bayer Science Fellow at Bayer AG, Crop Science Division) make the case for embracing and deciphering the complexity associated with these reactions, particularly in understanding Pd catalyst speciation more holistically. There is a need for better models and predictive tools for connecting Pd catalyst speciation events with the generation of multiple products so that the complexity can be better understood and discovery outcomes enhanced.

Original language	English
Article number	101255
Number of pages	3
Journal	Chem Catalysis
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.checat.2024.101255
Publication status	Published - 16 Jan 2025

Bibliographical note

Keywords

palladium
catalysis
mechanism
Sustainability
precious metals

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10.1016/j.checat.2024.101255

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abstract = "Pd-catalyzed cross-couplings have revolutionized chemical synthesis. Realizing a world that can make any organic molecular structure will undoubtedly require Pd-catalyzed cross-coupling as a tool to enable this high-brow vision. Here, Ian Fairlamb (professor at the University of York) and Mark Ford (Distinguished Bayer Science Fellow at Bayer AG, Crop Science Division) make the case for embracing and deciphering the complexity associated with these reactions, particularly in understanding Pd catalyst speciation more holistically. There is a need for better models and predictive tools for connecting Pd catalyst speciation events with the generation of multiple products so that the complexity can be better understood and discovery outcomes enhanced.",

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AB - Pd-catalyzed cross-couplings have revolutionized chemical synthesis. Realizing a world that can make any organic molecular structure will undoubtedly require Pd-catalyzed cross-coupling as a tool to enable this high-brow vision. Here, Ian Fairlamb (professor at the University of York) and Mark Ford (Distinguished Bayer Science Fellow at Bayer AG, Crop Science Division) make the case for embracing and deciphering the complexity associated with these reactions, particularly in understanding Pd catalyst speciation more holistically. There is a need for better models and predictive tools for connecting Pd catalyst speciation events with the generation of multiple products so that the complexity can be better understood and discovery outcomes enhanced.

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KW - catalysis

KW - mechanism

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Why deciphering complexity in Pd-catalyzed cross-coupling reactions matters

Abstract

Bibliographical note

Keywords

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