Why RIDL is not SIT

TY - JOUR

T1 - Why RIDL is not SIT

AU - Black, William C.

AU - Alphey, Luke

AU - James, Anthony A.

PY - 2011/8

Y1 - 2011/8

N2 - History teaches that sterile insect technique (SIT) is a feasible strategy for mosquito population suppression. Female killing (FK) technologies developed later theoretically had greater potential than SIT, but depended upon chromosomal translocations. Unfortunately these were genetically unstable. New transgenic strategies have been misinterpreted as a replacement for SIT. Instead these strategies provide a means to revisit FK. Conditional lethal mutations inserted into mosquito genomes allow for adjustment of the age of mortality, female-specific lethality, bisexual lethality and manipulation of germline-specific gene expression. A recent Aedes aegypti case study demonstrates the viability of one of these new transgenic strategies.

AB - History teaches that sterile insect technique (SIT) is a feasible strategy for mosquito population suppression. Female killing (FK) technologies developed later theoretically had greater potential than SIT, but depended upon chromosomal translocations. Unfortunately these were genetically unstable. New transgenic strategies have been misinterpreted as a replacement for SIT. Instead these strategies provide a means to revisit FK. Conditional lethal mutations inserted into mosquito genomes allow for adjustment of the age of mortality, female-specific lethality, bisexual lethality and manipulation of germline-specific gene expression. A recent Aedes aegypti case study demonstrates the viability of one of these new transgenic strategies.

UR - http://www.scopus.com/inward/record.url?scp=79960666250&partnerID=8YFLogxK

U2 - 10.1016/j.pt.2011.04.004

DO - 10.1016/j.pt.2011.04.004

M3 - Review article

C2 - 21659002

AN - SCOPUS:79960666250

SN - 1471-4922

VL - 27

SP - 362

EP - 370

JO - Trends in parasitology

JF - Trends in parasitology

IS - 8

ER -