Chris Elliott

Contact details

Type of addressPostal address
Postal codeYO10 5DD
CountryUnited Kingdom
Address lines
  • Biology
    University of York
    Wentworth Way
    York
    YO10 5DD

Phone: (01904) 328654

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations

Dr. Chris Elliott

Lecturer

Areas of expertise

  • Insect nervous systems
  • Drosophila neurobiology
  • Role of octopamine

PhD opportunities

The most common genetic cause of Parkinson’s disease (PD) is a mutation in the LRRK2 gene, G2019S. We have developed a new fly model, which exploits the homology of between fly and human. The proboscis extension response (PER) shows a marked decline in performance with G2019S expression, but not with other mutations in LRRK2. This loss of function is most marked when G2019S is expressed in the dopaminergic neurons. It can be rescued by drug application. We will use the extensive fly genetic toolbox to test the function of G2019S as a dominant negative kinase mutation, and to screen candidate genes which slow degeneration. We will support this by using drug application (L-DOPA, kinase inhibitors, glycolytic upregulation). This will provide a new view of LRRK2 neurophysiology in the whole organism, in a way that has not been possible in mouse models.

View all (5) »

Latest activities and conferences