The York Research Database

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model

Paape, D., Prendergast, C. T., Price, H. P., Doehl, J. S. P. & Smith, D. F., 14 Mar 2020

Article in Parasites & vectors

Exploring the Leishmania Hydrophilic Acylated Surface Protein B (HASPB) Export Pathway by Live Cell Imaging Methods

O'Toole, P. J., Price, H. P. & MacLean, L. M., 26 Sep 2016

Article in Methods in Molecular Biology

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei

Wright, M. H., Paape, D., Price, H. P., Smith, D. F. & Tate, E. W., 10 Jun 2016

Article in BMC Infectious Diseases

The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host

Price, H. P., Paape, D., Hodgkinson, M. R., Farrant, K., Doehl, J., Stark, M. & Smith, D. F., Nov 2013

Article in Molecular Microbiology

Imaging African trypanosomes

MacLean, L., Myburgh, E., Rodgers, J. & Price, H. P., 25 Jun 2013

Review article in Parasite immunology

Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei

Hemsworth, G. R., Price, H. P., Smith, D. F. & Wilson, K. S., Feb 2013

Article in Protein Science

A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei

Price, H. P., Hodgkinson, M. R., Wright, M. H., Tate, E. W., Smith, B. A., Carrington, M., Stark, M. & Smith, D. F., Jul 2012

Article in Biochimica et biophysica acta-Molecular cell research

The Orthologue of Sjögren's Syndrome Nuclear Autoantigen 1 (SSNA1) in Trypanosoma brucei Is an Immunogenic Self-Assembling Molecule

Price, H. P., Hodgkinson, M. R., Curwen, R. S., MacLean, L. M., Brannigan, J. A., Carrington, M., Smith, B. A., Ashford, D. A., Stark, M. & Smith, D. F., 20 Feb 2012

Article in PLoS ONE

Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress

Ramos, C. S., Yokoyama-Yasunaka, J. K. U., Guerra-Giraldez, C., Price, H. P., Mortara, R. A., Smith, D. F. & Uliana, S. R. B., Jan 2011

Article in Experimental parasitology

The stage-regulated HASPB and SHERP proteins are essential for differentiation of the protozoan parasite Leishmania major in its sand fly vector, Phlebotomus papatasi

Sadlova, J., Price, H. P., Smith, B. A., Votypka, J., Volf, P. & Smith, D. F., Dec 2010

Article in Cellular Microbiology

The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei

Price, H. P., Peltan, A., Stark, M. & Smith, D. F., Oct 2010

Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F., Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010

Article in Nature

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

Brannigan, J. A., Smith, B. A., Yu, Z., Brzozowski, A. M., Hodgkinson, M. R., Maroof, A., Price, H. P., Meier, F., Leatherbarrow, R. J., Tate, E. W., Smith, D. F. & Wilkinson, A. J., 5 Mar 2010

Article in Journal of Molecular Biology

Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

Price, H. P., Guether, M. L. S., Ferguson, M. A. J. & Smith, D. F., Jan 2010

Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Validation of a new method for immobilising kinetoplastid parasites for live cell imaging

Price, H. P., MacLean, L., Marrison, J., O'Toole, P. J. & Smith, D. F., Jan 2010

Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

TbARF1 influences lysosomal function but not endocytosis in procyclic stage Trypanosoma brucei

Price, H. P., Stark, M., Smith, B. & Smith, D. F., Oct 2007

Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Trypanosoma brucei ARF1 plays a central role in endocytosis and Golgi-lysosome trafficking

Price, H. P., Stark, M. & Smith, D. F., 1 Mar 2007

Article in Molecular Biology of the Cell

Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania

Mills, E., Price, H. P., Johner, A., Emerson, J. E. & Smith, D. F., Mar 2007

Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase

Denny, P. W., Shams-Eldin, H., Price, H. P., Smith, D. F. & Schwarz, R. T., 22 Sep 2006

Article in Journal of Biological Chemistry

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

Panethymitaki, C., Bowyer, P. W., Price, H. P., Leatherbarrow, R. J., Brown, K. A. & Smith, D. F., 1 Jun 2006

Article in Biochemical journal

ARL1 has an essential role in Tryponosoma brucei

Price, H. P., Goulding, D. & Smith, D. F., Aug 2005

Article in Biochemical Society transactions

Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes

Price, H. P., Panethymitaki, C., Goulding, D. & Smith, D. F., 15 Feb 2005

Article in Journal of Cell Science

Chemokine gene expression in toll-like receptor-competent and -deficient mice infected with Leishmania major

Antoniazi, S., Price, H. P., Kropf, P., Freudenberg, M. A., Galanos, C., Smith, D. F. & Müller, I., Sep 2004

Article in Infection and Immunity

Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major

Kropf, P., Freudenberg, M. A., Modolell, M., Price, H. P., Herath, S., Antoniazi, S., Galanos, C., Smith, D. F. & Müller, I., Apr 2004

Article in Infection and Immunity

Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites

Price, H. P., Menon, M. R., Panethymitaki, C., Goulding, D., McKean, P. G. & Smith, D. F., 28 Feb 2003

Article in Journal of Biological Chemistry