Mark Christian Leake

Contact details

Type of addressPostal address
Postal codeYO10 5DD
CountryUnited Kingdom
Address lines
  • Biology
    University of York
    Wentworth Way
    York
    YO10 5DD

Phone: (01904) 328566

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Prof. Mark Christian Leake, FInstP, FRMS, FRSB

Anniversary Professor

  1. 2019
  2. Unveiling the multi-step solubilization mechanism of sub-micron size vesicles by detergents

    Dalgarno, P. A., Juan-Colás, J., Hedley, G. J., Piñeiro, L., Novo, M., Perez-Gonzalez, C., Samuel, I. D. W., Leake, M. C., Johnson, S., Al-Soufi, W., Penedo, J. C. & Quinn, S. D., 9 Sep 2019

    Article in Scientific Reports

  3. 2018
  4. ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance

    Pu, Y., Li, Y., Jin, X., Tian, T., Ma, Q., Zhao, Z., Lin, S., Chen, Z., Li, B., Yao, G., Leake, M. C., Lo, C-J. & Bai, F., 21 Nov 2018

    Article in Molecular Cell

  5. Single-molecule imaging of DNA gyrase activity in living Escherichia coli

    Stracy, M., Wollman, A., Kaja, E., Gapinski, J., Lee, J-E., Leek, V. A., McKie, S. J., Mitchenall, L. A., Maxwell, A., Sherratt, D. J., Leake, M. C. & Zawadzki, P., 16 Nov 2018

    Article in Nucleic Acids Research

  6. Molecular coordination of Staphylococcus aureus cell division

    Foster, S., Lund, V. A., Wacnik, K., Turner, R. D., Cotterell, B. E., Walther, C. G., Fenn, S. J., Grein, F., Wollman, A., Leake, M. C., Olivier, N., Cadby, A., Mesnage, S. & Jones, S., 21 Feb 2018

    Article in eLife

  7. 2017
  8. Transcription factor clusters regulate genes in eukaryotic cells

    Wollman, A., Shashkova, S., Hedlund, E. G., Friemann, R., Hohmann, S. & Leake, M. C., 25 Aug 2017

    Article in eLife

  9. Imaging the cell

    Carrascosa, J. L. & Leake, M. C., 3 Aug 2017

    Article in Biophysical Reviews

  10. We must ensure that fortune favours the 500

    Leake, M. C., 20 Apr 2017, Times Higher Education Supplement.

    Research output: Contribution to specialist publicationArticle

  11. Frequent exchange of the DNA polymerase during bacterial chromosome replication

    Beattie, T. R., Kapadia, N., Nicolas, E., Uphoff, S., Wollman, A., Leake, M. C. & Reyes-Lamothe, R., 31 Mar 2017

    Article in eLife

  12. 2016
  13. New advances in chromosome architecture

    Leake, M. C., 14 Jun 2016, Chromosome Architecture: Methods and Protocols . Leake, M. C. (ed.). Springer, 5 p. (Methods in Molecular Biology; vol. 1431).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  14. Biophysics: tools and techniques

    Leake, M. C., 2016, CRC PRESS-TAYLOR & FRANCIS GROUP.

    Research output: Book/ReportBook

  15. Chromosome Architecture

    Leake, M. C. (ed.), 2016, Springer. (Methods in Molecular Biology)

    Research output: Book/ReportBook

  16. 2015
  17. Plasmonics, Tracking and Manipulating, and Living Cells: general discussion.

    Cordes, T., Moerner, W., Orrit, M., Sekatskii, S., Faez, S., Borri, P., Goswami, H. P., Clark, A., El-Khoury, P., Mayr, S., Mika, J., Lyu, G., Cross, D., Balzarotti, F., Langbein, W., Sandoghdar, V., Jens, M., Chowdhury, A., Meixner, A. J., van Hulst, N. & 7 othersLounis, B., Stefani, F., Cichos, F., Dahan, M., Novotny, L., Leake, M. C. & Yang, H., 1 Dec 2015

    Article in FARADAY DISCUSSIONS

  18. Innovative Science: The London Times, Letter to the Editor

    Leake, M. C., 2015.

    Research output: Contribution to conferencePaper

  19. 2014
  20. Localisation and interactions of the Vipp1 protein in cyanobacteria

    Bryan, S. J., Burroughs, N. J., Shevela, D., Yu, J., Rupprecht, E., Liu, L-N., Mastroianni, G., Xue, Q., Llorente-Garcia, I., Leake, M. C., Eichacker, L. A., Schneider, D., Nixon, P. J. & Mullineaux, C. W., Dec 2014

    Article in Molecular Microbiology

  21. Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation

    Llorente-Garcia, I., Lenn, T., Erhardt, H., Harriman, O. L., Liu, L-N., Robson, A., Chiu, S-W., Matthews, S., Willis, N. J., Bray, C. D., Lee, S-H., Shin, J. Y., Bustamante, C., Liphardt, J., Friedrich, T., Mullineaux, C. W. & Leake, M. C., Jun 2014

    Article in Biochimica et Biophysica Acta. Bioenergetics

  22. Independent mobility of proteins and lipids in the plasma membrane of Escherichia coli

    Nenninger, A., Mastroianni, G., Robson, A., Lenn, T., Xue, Q., Leake, M. C. & Mullineaux, C. W., 30 Apr 2014

    Article in Molecular Microbiology

  23. 2013
  24. Single-molecule cellular biophysics

    Leake, M. C., 2013, Cambridge University Press.

    Research output: Book/ReportBook

  25. 2012
  26. In vivo architecture and action of bacterial structural maintenance of chromosome proteins

    Badrinarayanan, A., Reyes-Lamothe, R., Uphoff, S., Leake, M. C. & Sherratt, D. J., 26 Oct 2012

    Article in Science

  27. 2011
  28. 2010
  29. Signal-dependent turnover of the bacterial flagellar switch protein FliM

    Delalez, N. J., Wadhams, G. H., Rosser, G., Xue, Q., Brown, M. T., Dobbie, I. M., Berry, R. M., Leake, M. C. & Armitage, J. P., 22 Jun 2010

    Article in Proceedings of the National Academy of Sciences of the United States of America

  30. 2009
  31. A novel multiple particle tracking algorithm for noisy in vivo data by minimal path optimization within the spatio-temporal volume

    Xue, Q. & Leake, M. C., 1 Jan 2009, Proceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009. p. 1158-1161 4 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  32. 2008
  33. Parts exchange: Why molecular machines are like used cars

    Leake, M. C., Wadhams, G. H. & Armitage, J. P., 1 Feb 2008

    Article in Biologist

  34. 2007
  35. 2006
  36. Stoichiometry and turnover in single, functioning membrane protein complexes

    Leake, M. C., Chandler, J. H., Wadhams, G. H., Bai, F., Berry, R. M. & Armitage, J. P., 21 Sep 2006

    Article in Nature

  37. 2005
  38. Direct observation of steps in rotation of the bacterial flagellar motor

    Sowa, Y., Rowe, A. D., Leake, M. C., Yakushi, T., Homma, M., Ishijima, A. & Berry, R. M., 6 Oct 2005

    Article in Nature

  39. 2004
  40. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

    Makarenko, I., Opitz, C. A., Leake, M. C., Neagoe, C., Kulke, M., Gwathmey, J. K., del Monte, F., Hajjar, R. J. & Linke, W. A., 1 Oct 2004

    Article in Circulation Research

  41. Association of the Chaperone B-crystallin with Titin in Heart Muscle

    Bullard, B., Ferguson, C., Minajeva, A., Leake, M. C., Gautel, M., Labeit, D., Ding, L., Labeit, S., Horwitz, J., Leonard, K. R. & Linke, W. A., 27 Feb 2004

    Article in The Journal of biological chemistry

  42. 2003