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Mr. Richard Spears

(Former)

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  1. 2021

  2. A tale of two bioconjugations: pH controlled divergent reactivity of protein a-oxo aldehydes in competing a-oxo-Mannich and catalyst-free aldol ligations

    Keenan, T., Spears, R., Akkad, S., Mahon, C. S., Hatton, N., Walton, J., Noble, A., Yates, N., Baumann, C. G., Parkin, A., Signoret, N. Y. M. & Fascione, M. A., 9 Nov 2021, (E-pub ahead of print)

    Article in ACS Chemical Biology

  3. 2019

  4. BIOCONJUGATION OF POLYPEPTIDES

    Fascione, M. A., Spears, R. J., Brabham, R. L., Budhadev, D. & Keenan, T., 4 Apr 2019, IPC No. A61K 47/54, C07K 1/13, C07K 1/107, Patent No. WO/2019/063958, 27 Sep 2017

    Research output: Patent

  5. Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus

    Yates, N. D. J., Brabham, R. L., Spears, R. J., Keenan, T., Helliwell, P. A., Pugh, D. S., Parkin, A., Hurst, G. A. & Fascione, M. A., 26 Mar 2019

    Article in JOURNAL OF CHEMICAL EDUCATION

  6. 2018

  7. Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

    Spears, R. J., Brabham, R. L., Budhadev, D., Keenan, T., McKenna, S. E., Walton, J., Brannigan, J. A., Brzozowski, A. M., Wilkinson, A. J., Plevin, M. J. & Fascione, M. A., 7 Jul 2018

    Article in Chemical Science

  8. Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif

    Thompson, A. J., Spears, R. J., Zhu, Y., Suits, M. D. L., Williams, S. J., Gilbert, H. J. & Davies, G. J., 1 May 2018

    Article in Acta crystallographica. Section D, Structural biology

  9. Palladium-unleashed proteins: gentle aldehyde decaging for site-selective protein modification

    Brabham, R. L., Spears, R. J., Walton, J., Tyagi, S., Lemke, E. & Fascione, M. A., 6 Feb 2018

    Article in Chemical Communications

  10. 2017

  11. Illuminating the spatio-temporal dynamics of lipopolysaccharide in the Gram- negative outer membrane

    Leaman, R. M., Spears, R. J., Fascione, M. A., Pushkin, D., Coles, M. C. & Baumann, C. G., Jul 2017.

    Research output: Contribution to conference › Poster › peer-review

  12. 2016

  13. Site-selective incorporation and ligation of protein aldehydes

    Spears, R. J. & Fascione, M. A., 30 Jun 2016

    Review article in Organic and Biomolecular Chemistry

  14. 2015

  15. Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism

    Thompson, A. J., Speciale, G., Iglesias-Fernández, J., Hakki, Z., Belz, T., Cartmell, A., Spears, R. J., Chandler, E., Temple, M. J., Stepper, J., Gilbert, H. J., Rovira, C., Williams, S. J. & Davies, G. J., 27 Apr 2015

    Article in Angewandte Chemie International Edition

  16. Structure of the GH76 -mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron

    Thompson, A. J., Cuskin, F., Spears, R. J., Dabin, J., Turkenburg, J. P., Gilbert, H. J. & Davies, G. J., 1 Jan 2015

    Article in Acta Crystallographica. Section D, Biological Crystallography

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