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Mrs. Wendy Anne Offen

(Former)

  1. 2020
  2. Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine

    Weber, P., Thonhofer, M., Averill, S., Davies, G. J., Santana, A. G., Müller, P., Nasseri, S. A., Offen, W. A., Pabst, B. M., Paschke, E., Schalli, M., Torvisco, A., Tschernutter, M., Tysoe, C., Windischhofer, W., Withers, S. G., Wolfsgruber, A., Wrodnigg, T. M. & Stütz, A. E., 3 Sep 2020

    Article in MOLECULES

  3. Profiling substrate promiscuity of wild-type sugar kinases for multifluorinated monosaccharides

    Keenan, T., Parmeggiani, F., Malassis, J., Fontenelle, C., Vendeville, J-B., Offen, W. A., Both, P., Huang, K., Marchesi, A., Heyam, A. P., Young, C., Charnock, S. J., Davies, G. J., Linclau, B., Flitsch, S. L. & Fascione, M. A., 2 Jul 2020

    Article in Cell Chemical Biology

  4. 2019
  5. 2018
  6. Functional and informatics analysis enables glycosyltransferase activity prediction

    Yang, M., Fehl, C., Lees, K. V., Lim, E-K., Offen, W. A., Davies, G. J., Bowles, D. J., Davidson, M. G., Roberts, S. J. & Davis, B. G., 12 Nov 2018

    Article in NATURE CHEMICAL BIOLOGY

  7. Competitive and covalent inhibitors of human lysosomal retaining exoglucosidases

    Breen, I. Z., Artola, M., Wu, L., Beenakker, T., Offen, W. A., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 22 Jan 2018, eLS.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  8. Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor

    Schröder, S. P., Wu, L., Artola, M., Hansen, T., Offen, W. A., Ferraz, M. J., Li, K-Y., Aerts, J. M. F. G., Van Der Marel, G. A., Codée, J. D. C., Davies, G. J. & Overkleeft, H. S., 2018

    Article in Journal of the American Chemical Society

  9. 2017
  10. Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

    Schroder, S. P., van de Sande, J. W., Kallemeijn, W. W., Kuo, C-L., Artola, M., van Rooden, E. J., Jiang, J., Beenakker, T. JM., Florea, B. I., Offen, W. A., Davies, G., Minnaard, A. J., Aerts, H., Codee, J. D., Van Der Marel, G. A. & Overkleeft, H. S., 6 Nov 2017

    Article in Chemical Communications

  11. 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

    Artola, M., Wu, L., Ferraz, M. J., Kuo, C. L., Raich, L., Breen, I. Z., Offen, W. A., Codée, J. D. C., Van Der Marel, G. A., Rovira, C., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 26 Jul 2017

    Article in ACS Central Science

  12. Structural and functional insight into human O-GlcNAcase

    Roth, C., Chan, O. Y., Offen, W. A., Hemsworth, G. R., Willems, L. I., King, D. T., Varghese, V., Britton, R., Vocadlo, D. J. & Davies, G. J., 1 Jun 2017

    Article in NATURE CHEMICAL BIOLOGY

  13. Carba-Cyclophellitols are Neutral Retaining Glucosidase Inhibitors

    Beenakker, T. J. M., Wander, D., Offen, W. A., Artola, M., Raich, L., Ferraz, M. J., Li, K-Y., Houben, J. H. P. M., Rijssel, E. R. V., Hansen, T., Marel, G. A. V. D., Codée, J. D. C., Aerts, J. M. F. G., Rovira, C., Davies, G. J. & Overkleeft, H. S., 2017

    Article in Journal of the American Chemical Society

  14. 2016
  15. 2015
  16. 2014
  17. 2011
  18. Structure and Activity of Paenibacillus polymyxa Xyloglucanase from Glycoside Hydrolase Family 44

    Ariza, A., Eklöf, J. M., Spadiut, O., Offen, W. A., Roberts, S. M., Besenmatter, W., Friis, E. P., Skjøt, M., Wilson, K. S., Brumer, H. & Davies, G., 30 Sep 2011

    Article in Journal of Biological Chemistry

  19. 2009
  20. 2008
  21. Structural and biochemical evidence for a boat-like transition state in beta-mannosidases

    Tailford, L. E., Offen, W. A., Smith, N. L., Dumon, C., Morland, C., Gratien, J., Heck, M-P., Stick, R. V., Bleriot, Y., Vasella, A., Gilbert, H. J. & Davies, G. J., 23 May 2008

    Article in NATURE CHEMICAL BIOLOGY

  22. 2007
  23. 2006
  24. Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification

    Offen, W., Martinez-Fleites, C., Yang, M., Kiat-Lim, E., Davis, B. G., Tarling, C. A., Ford, C. M., Bowles, D. J. & Davies, G. J., 22 Mar 2006

    Article in EMBO Journal

  25. 2003
  26. Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9 angstrom resolution

    Vincent, F., Charnock, S. J., Verschueren, K. H. G., Turkenburg, J. P., Scott, D. J., Offen, W. A., Roberts, S., Pell, G., Gilbert, H. J., Davies, G. J. & Brannigan, J. A., 11 Jul 2003

    Article in Journal of Molecular Biology

  27. 1999
  28. 1998
  29. 1997